ABCDEFG 1 Nguyen Thanh Liem
ABCDEF 2 Vu Duy Chinh
BCDEF 3 Nguyen Thi Thinh
ABCDEF 3 Ngo Duy Minh
BCDEF 1 Hoang Minh Du
Corresponding Author: Liem Nguyen Thanh (Liem NT), e-mail: v.liemnt@vinmec.com Conflict of interest: None declared Source of support: Vinmec Research Institute of Stem Cell and Gene Technology’s Internal Grant
Case series
Patient : Male, 14 • Female, 11
Final Diagnosis : Improvement in bowel functions after bone marrow mononuclear cells transplantation
Symptoms : Impaired bowel functions • spina bifida
Medication : —
Clinical Procedure : Bone Marrow-Derived Mononuclear Cell Transplantation
Specialty : Pediatrics and Neonatology
Objective : Congenital defects/diseases
Background : Bowel dysfunction is observed in 42.2–71.2% of patients with spina bifida. Traditional treatments yield limited results. The objective of this paper is to report on improvement in bowel function in 2 children with spina bifida following bone marrow-derived mononuclear cells transplantation.
Case reports : Two patients – 14 years old and 11 years old – with bowel dysfunction after myelomeningocele repair underwent 2 BMMNC transplantations without complications. Those patients had normal defecation, assessed through follow-ups of 21 months and 16 months, respectively.
Conclusions : BMMNC transplantation can improve bowel function, as demonstrated in 2 patients with spina bifida.
MeSH Keywords: Adult Stem Cells • Bone Marrow Transplantation • Spina Bifida Occulta
Full-text PDF: https://www.amjcaserep.com/abstract/index/idArt/90980 1
