Abstract
Object: Evaluate the results of concurrent chemotherapy in combination with volumetric modulated arc radiation therapy (VMAT/RapidArc) for the treatment of head and neck cancers, first 2 years experience at Vinmec Times City International Hospital.
Methods: Five patients treated from January 2015 to January 2017 were analyzed. Patients were treated with VMAT and SIB in 35 fractions for a total dose of 70Gy (PTV_70), 63Gy (PTV_63) and 56Gy (PTV_56), respectively. For organs at risk, the mean dose, V50Gy were analysed. For targets, Dmean, D98%, D2%, conformity and homogeneity indexes were calculated. Toxicity was graded according to CTCAE v4.0.
Results: 05 patients were treated and completed all treatment. Complete response was seen in 4 patients, 01 tonsil cancer achieved partial resonse. Grade 3 acute sequalea of somatitis, esophagitis occurred in first patient that resulted in interuption of 01 week for supportive care. Late effects were grade 1 xerostomia in 2 patients, no speech difficulty, no dysphagia and mandible pain was reported. All patients were met the radiotherapy plan compliance criteria in terms of dose calculation and quality assurance.
Conclusions: VMAT-SIB in concurrent combination with chemotherapy is safe and high efficiency in mangament of advanced stage head and neck cancers in terms of overall survival and progression-free survival with acceptable acute and late toxicities but need to enroll many more patient to confirm these findings.
Để được tư vấn trực tiếp, Quý Khách vui lòng bấm số 1900 232 389 (phím 0 để gọi Vinmec) hoặc đăng ký lịch khám tại viện TẠI ĐÂY. Nếu có nhu cầu tư vấn sức khỏe từ xa cùng bác sĩ Vinmec, quý khách đặt lịch tư vấn TẠI ĐÂY. Tải ứng dụng độc quyền MyVinmec để đặt lịch nhanh hơn, theo dõi lịch tiện lợi hơn
